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Ketoconazole (Generic Nizoral) is a synthetic broad-spectrum antifungal agent available in scored white to off-white tablets. Ketoconazole belongs to the class of drugs called imidazoles. Generic Nizoral tablets are indicated for the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. These infections generally pass through the blood stream, and include yeast infections of the mouth, skin, urinary tract.

Ketoconazole indications and usage

Ketoconazole is an antifungal medication that blocks the formation of cortisol in the adrenal glands and for that reason is used in the treatment of Cushing’s disease. Ketoconazole tablets are indicated for the treatment of patients with systemic fungal infections, yeast infections, severe recalcitrant cutaneous dermatophyte infections who have not responded to topical therapy or oral griseofulvin, or who are unable to take griseofulvin. Results of treatment may not be seen for 1 or 2 weeks and the duration of treatment may last up to several months. The usual dose for dogs and cats is 2.2-13mg/pound by mouth every 12 -24 hours depending on the disease.

What should I know before taking ketoconazole

Do not give ketoconazole if your pet is being given astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Tell your doctor if you have liver disease, or if you are being taken antacids, stomach acid reducers or stomach ulcer medications. Tell your doctorabout any medications you are taking, especially: cyclosporine, methylprednisolone, antacids, warfarin. In rare cases anaphylaxis has been reported after the first dose. Several cases of hypersensitivity reactions including urticaria have also been reported. Ketoconazole may alter the metabolism of cyclosporine, tacrolimus, and methylprednisolone, resulting in elevated plasma concentrations of the latter drugs. Dosage adjustment may be required if cyclosporine, tacrolimus, or methylprednisolone are given concomitantly with ketoconazole.