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Medicines can often help control chronic pain. There are three main types of pain medicine: non-opioids, such as NSAIDs; anaesthetics, such as lidocaine and EMLA; adjuvant drugs, such as tricyclic antidepressants and anticonvulsants. Pain that starts in the nerves themselves, "neuropathic pain," is best treated with antidepressants and anticonvulsants. However, if someone has neuropathic pain and also has depression or seizures, these medications may be prescribed in traditional doses to treat both conditions at the same time. When pain is coming from a specific place, but is difficult to manage with the usual medicines, nerve blocks may be performed, usually by an anesthesiologist.

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Generic Neurontin is used for treating seizures associated with epilepsy. It may also be used for treating nerve pain associated with herpes zoster (shingles) infection (postherpetic neuralgia).

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For most pain, doctors and nurses use a step-up approach to pain medicine. A combination of different types of pain relief medication will usually be used to relieve pain. The pain is continuously being treated because a constant amount of pain medicine is being delivered to your bloodstream. All these medicines can cause side effects and should be taken exactly as they are prescribed. In some cases, it may take several weeks before medicines work to reduce pain. To avoid dangerous drug interactions, tell your doctor all the medicines you are taking.